Lead Criminalist Horatio Caine is targeted by adversaries old and new. As the danger grows for Caine, he and the rest of his team - Calliegh, Eric, Alexx, Ryan, Frank and Natalia - must go the limit to solve their biggest cases yet. The team collects and analyzes the evidence to solve crimes and vindicate the victims.

Originally broadcast on CBS during the 2006-2007 season. Contains all 24 episodes from the fifth season ; episodes appear in order of their original air dates. Special features: Disc 1: Episode 501 with audio commentary by Sam Hill, Sunil Nayar and Brian O'Neill; Episode 503 with audio commentary by Sam Hill, Adam Rodriguez and Carey Meyer; "Rio Grand: CSI: Miami goes to Rio" featurette ; Disc 2: Episode 505 with audio commentary by Jonathan Togo, Corey Miller and Larry Detwiler; episode 507 with audio commentary by Eva La Rue and John Haynes; "If looks could kill: special F/X makeup" featurette. Special features: Disc 4: Episode 515 with audio commentary by Karen Gaviola and Gonzalo Menendez; "Turning up the heat: the look of CSI: Miami" featurette ; Disc 5: "Dressing the part" featurette ; Disc 6: "The real MDPD with Jonathan Togo" featurette ; PC CD-ROM playable demo "CSI: Crime Scene Investigation: Hard Evidence" (Rated: M for Mature - 17+; blood and gore, sexual themes, violence).

Disc 1 :Rio -- Going under -- Death pool 100 -- If looks could kill ; -- Disc 2 : Death Eminent -- Curse of the coffin -- High octane -- Darkroom ; -- Disc 3 : Going, going, gone -- Come as you are -- Backstabbers -- Internal affairs ; -- Disc 4 : Throwing heat -- No man's land -- Man down -- Broken home ; -- Disc 5 : A grizzly murder -- Triple threat -- Bloodline -- Rush ; -- Disc 6 : Just murdered -- Burned -- Kill switch -- Born to kill.